Creative BioMart provides T cell epitope mapping and discovery services based on commercial or custom peptide libraries. Our T-cell response-defined epitope analysis can help researchers understand the nature of protective or deleterious T-cell responses in diseases with well-defined target antigens to support subsequent drug development and design. 

Epitope Mapping and Drug Development

T-cell epitopes are the building blocks of proteins on antigen-presenting cells that trigger an immune response after T-cell recognition and binding. The identification of these epitopes is critical for the development of effective immune disease therapies. The process of identifying specific peptide sequences on an antigen that elicits an immune response by binding to antibodies or MHC molecules is called epitope mapping and usually involves T cells and antibodies. Epitope mapping of ex vivo T cells can determine the precise location, number, and size of T cell epitopes, which can be used to aid deimmunization and help reduce the risk of clinical immunogenicity. Epitope identification requires high-throughput systematic screening of antigens, but the antigen's own structure (conformation, binding domain) may influence this work.  However, the development of T-cell therapeutic targets relies on a comprehensive understanding of the antigen, so epitope mapping by peptide libraries is necessary. Peptide libraries used to display multiple short linear peptide fragments can be used to infer specific T cell epitopes, some highly sensitive information that can help reduce the risk of clinical immunogenicity.

Featured T Cell Epitope Mapping Service

We provide researchers with T-cell epitope mapping services to help researchers tap more potential knowledge and accelerate the development of new treatments and drugs. This service is based on featured peptide libraries. The identification of T cell epitopes is critical for the development of effective immune disease therapies, and peptide libraries are designed so that overlapping fragments of the entire antigen are displayed. T cell cultures or purified receptors are then added to the library for testing, and the identification of properties is assessed by flow cytometry and other cellular assays. The method of peptide library testing can achieve efficient T-epitope discovery, which is of great benefit to vaccine development. T-cell epitope mapping and discovery through peptide libraries can be useful in the study of viral infections, autoimmune diseases, and cancers. In addition, epitope mapping services can also achieve accurate mapping of T cell epitopes. Our platform also provides analytical services based on custom immunogenic peptide libraries, helping you to assay highly sensitive T cell populations to identify T cell epitopes in your samples.

Fig.1 Service workflow for T cell epitope mapping.

Creative BioMart offers high quality ELISpot assays, providing our customers with a wide range of analytical options. Based on our advanced detection systems, we provide biomedical services to clients seeking to quantify and detect antibody-antigen immune response interactions. If you are interested in our services, please contact us for cooperation.