Creative BioMart is able to accelerate the rapid generation of various MHC alleles, and sophisticated peptide synthesis technologies enabled the production of long peptides and even small proteins. Our stable synthesis of peptides improves the availability and reliability of peptide-major histocompatibility complex (pMHC) reagents for applications related to T cell visualization and T cell depletion/concentration technologies.

Introduction of MHC-associated Peptide Synthesis

Peptides play key roles in fundamental biochemical and physiological processes and are critical to many aspects of biomedical research, in particular the stable high-quality synthesis of MHC-associated peptides facilitates the development of adoptive T cell therapies. It will allow epitope scanning through the entire genome of emerging pathogens, thus facilitating vaccine development.

Synthetic MHC-associated peptides have been used to sensitize target cells and thus screen for epitopes recognized by T cells. Firstly, MHC-associated peptide synthesis allows the simple introduction of amino acids whose functions stabilize proteins by enhanced H-bonding, intra-chain cross-linking or intramolecular cross-linking and immobilization or conjugation. Secondly, higher yields of MHC-associated peptides. Thirdly, it simplifies the controlled generation of peptides for biomedical use.

Our MHC-associated Peptide Synthesis

We offer high quality custom peptide synthesis services including research peptides, specialized MHC-associated peptide synthesis and peptide purification to help select peptide specifications for your MHC-associated research.

• Our services choices

You can choose what you need for relevant peptides research according to different alleles and MHC molecules.

• MHC-associated peptide design
• Amino acid properties analysis
• Peptide purity ensuring
• Measurement of concentration

• Our peptide analysis

After peptide synthesis, each peptide is routinely analyzed by LC-MS, MALDI-MS or HPLC to confirm the identity and quality of your custom peptide.

• Amino acid analysis
• MHC- associated Peptide sequence analysis by mass spectrometry
• Residual solvent determination and moisture determination
• Solubility testing or stability testing
• Toxicity, sterility, endotoxin, bioburden testing

• Our synthesis methods

Our team can carry out various synthesis methods, such as solid phase peptide synthesis (SPPS), liquid phase peptide synthesis (LPPS) and high throughput synthesis.

We offer the most preferred technique for peptide chemical synthesis and enables the production of long polypeptides allowing peptide synthesis by automated applications. SPPS easily enables some post-translational backbone modifications and insertion of unnatural amino acids. LPPS accomplishes higher quality, lower reagent consumption, and easier fouling. We apply LPPS to the large-scale synthesis of small peptides such as dipeptides or tripeptides.

Advantages of Creative BioMart

• High success rate of MHC-associated peptide synthesis
• Multiple MHC molecules and allele selections
• Years of experience in synthesizing peptides
• Multiple synthesis methods
• Industry-leading speed of peptide synthesis

Applications

• Solid-phase peptide synthesis (SPPS)

Synthesis of long peptides can be used to develop peptide-major histocompatibility complex (pMHC) reagents for clinical use

• Liquid phase peptide synthesis (LPPS)

The synthesis of truncated short peptides improves the sensitivity of target cells to be easily captured by MHC molecules, contributing to the discovery of most epitopes of cytotoxic T lymphocytes in MHC-associated studies.

Turnaround Time

3 - 4 weeks

Our service is highly efficient with turnaround times of 3-4 weeks. We provide the final product for each peptide, as well as HPLC and MS reports, including appearance, quantity, molecular weight and purity analysis reports.

Creative BioMart has extensive and long-standing expertise in custom MHC-associated peptide synthesis services. We provide the highest quality custom peptides for your research, no matter how complex or unusual the peptide sequence. If you are interested in our services, please contact us for more detailed information.