Creative BioMart is not only an expert in MHC-associated peptide modifications, but also design and manufacture the highest quality specialty peptides to assist you in your MHC-associated peptide immunotherapy and vaccine development field research.

Introduction of MHC-associated Peptide Modification

T cells express T cell receptors (TCR) that recognize short peptide antigens in the context of major histocompatibility class (MHC) molecules. This recognition process generates a series of cytokine-mediated signals that help control the immune response. Modification of MHC-associated peptides is desirable for the design of vaccines containing unnatural, biostable MHC peptides. Effects of peptide backbone modification on T cell mediates recognition of tumor-associated antigens bound to MHC.

Peptides are modified in various ways, such as synthesized as biotin, fluorescent dyes, phosphorylation, methylation, acylation, acetylation, unnatural amino acids, etc. Modifications can also be classified as N-terminal modifications, C-terminal modifications, side chain modifications, amino acid modifications and backbone modifications. MHC-associated peptide modification is mainly based on changing the main chain structure or side chain motifs as an important way. The effect of such modifications on MHC affinity and T-cell activation was measured. Many of these modifications can reduce or enhance T-cell responses.

Our MHC-associated Peptide Modification

It was found that many MHC peptide antigens mimic the activity of possible T-cell responses. Our highly skilled scientific staff ensures that the most appropriate methods and techniques are selected for your MHC-associated peptide project, targeting complex and abnormal sequences of modified and labeled peptides. Our custom peptide modifications include, but are not limited to, those in the table below.

Each of our modified peptides will be analyzed by LC-MS, MALDI-MS or HPLC for each specialty to confirm its identity and quality. A variety of peptide analysis options are available. We will also provide a quality analysis of these documents.

• Amino acid analysis
• HPLC
• Residual solvent determination
• Solubility testing

Advantages of Creative BioMart

• Collaboration with experienced immunology scientists
  Our technical and application support team can advise on MHC-associated peptide solubilization, experimental design and analysis.
• The most advanced technology and reliable quality control
  Our powerful peptide library and wide selection of MHC genes allow us to design the most suitable functional peptide for your experiment.
• Accurate analytical platform and quality testing
  Our modified MHC-associated peptides are subject to strict 100% HPLC-MS quality control, and each peptide must meet MS analysis and final criteria to pass quality control testing.
• Multiple application pathways
  Our modified peptides are used extensively in MHC-associated studies for T-cell epitope mapping, B-cell epitope mapping, ELISPOT, protein-protein interactions, cellular assays, and other applications.
• Economical and fast delivery
  We provide high quality peptide modifications at a fair price and quickly present results for your MHC studies.

Turnaround Time

3 - 4 weeks

Our service is highly efficient with turnaround times of 3-4 weeks. We provide the final modification product for each peptide, as well as HPLC and MS reports.

Creative BioMart provides you with the exact modifications of MHC-associated peptides so that your research results can perform well, as MHC-associated research revolves heavily around the peptides that bind to it. In addition, we provide the knowledge, excellent customer support and fast turnaround time to save you valuable time. If you are interested in our services, please contact us for more detailed information.