Major histocompatibility complex (MHC) class I and II molecules are a large number of peptides presented on the cell surface (constituting the immunopeptidome) that are important for both basic and translational medical research. For basic medical research, the immune peptide panel is an important means to understand immune responses and immune molecules. For translational medicine research, an accurate understanding of the immunopeptidome can directly drive and guide the development of next-generation vaccines and immunotherapies to combat autoimmunity, infectious diseases, and cancer. Mass spectrometry-based platforms for the identification and quantification of MHC-related peptides enhance their biological applications to accelerate the development of biotherapeutics and therapeutic biological proteins for immune-related diseases.

Creative BioMart has developed a variety of proteomic analysis services that can be used to test the origin, size, structure, and other information of peptides in Peptide-MHC (pMHC). This service can also be used to identify and quantify potential targets and biomarkers in samples, providing evidence for immunogenicity assessment.

Our Services

• pMHC Screening and Quantification

Creative BioMart is a provider of immune-related proteomics services for the quantification and screening of MHC-binding peptides involved in immune response initiation. We feature mass spectrometry combined with multivariate analysis to identify peptides recognized by MHC molecules in immune abnormalities caused by specific drug stimuli, disease or infection.

• Exogenous Antigen Presentation Assay

Creative BioMart offers assays for exogenous antigen presentation based on methods based on MHC-Associated Peptide Proteomics (MAPPS) analysis and the resolution of MHC complexes in antigen presenting cells (APCs). The service is designed to help researchers identify peptides presented to T cells by APCs, parse MHC complexes isolated from APCs, and discover more details.

• BioNMR Service for Peptide-MHC Complexes

Creative BioMart provides analytical services for peptide-MHC and protein nuclear magnetic resonance spectroscopy (BioNMR) for structure determination and fragment screening of MHC complexes.

• pMHC Structure Modeling

Creative BioMart offers efficient and reliable pMHC modeling tools to determine the 3D structure of pMHC complexes through this interesting and creative solution, thus revealing the molecular basis of important immune responses.

Project Workflow

Creative BioMart has many years of testing services experience in the field of proteomics. We have a team of immunologists who can help clients with analytical tests and answer questions about their data analysis. We are committed to being a leading expert in the field of MHC solutions, able to provide customers with the highest quality and most timely service, and successfully complete each MHC proteomics project. We look forward to our advanced instruments, technologies and resources to facilitate your projects and advance your trials. If you are interested in our services, please contact us for a quote.