Stable MHC cell lines have shown great capacity in many fields, especially in immunotherapy, drug screening and gene function studies. With our extensive customization experience, Creative BioMart can offer customization services for stable MHC cell lines according to your requirements. Our services include cell lysate constructs with high expression of MHC molecules, MHC knockout cell line constructs, and MHC knockdown cell line constructs.

MHC Cells Construction

Powerful MHC cell lines are an important tool for understanding disease mechanisms and validating potential therapeutic targets, providing useful tools to study disease-responsive T cell responses, helping to overcome the significant challenges of obtaining the right controls during therapeutic assay development, and enabling effective exploration of the relationship between genotype and phenotype.

We customize MHC cells for your unique process, utilizing the most advanced genome editing techniques of knockout, knock-in, and everything in between to generate targeted modifications of any gene based on your target cell line.

Fig.1 MHC cell line customization process.

Our Services

• Over-expression MHC Cell Lysate Construction. We provide custom services for the construction of MHC highly expressed cell lines and their lysates, enabling researchers to obtain lysates of cells highly expressing MHC molecules to test the role of MHC molecules in relevant diseases. Our molecular biology team provides the entire process from strategy design to obtaining MHC-expressing cell lysates.
• MHC Knockout Cell Line Customization Service. We provide MHC knockout cell line construction services based on CRISPR/Cas9 system gene editing technology, which enables targeted editing of MHC molecular regions to obtain MHC molecular knockout cell lines. Our molecular biology team provides comprehensive knockout strategy design and subsequent cell line evaluation services to help you and your research get off to a fast start.
• MHC Knockdown Cell Line Customization Service. We offer RNA interference-based MHC knockdown cell line construction services that can be used to study the role of MHC signaling and to examine the complex role of MHC molecular signaling in immune-related signaling. Our molecular biology team provides comprehensive interference strategy design and subsequent cell line evaluation, which can help researchers gain access to more useful molecular and cellular tools.

Our Outstanding Strengths

• Optimized CRISPR editing platform to ensure quality at every stage and generate well-characterized cell lines.
• Powerful cell products with high productivity and excellent stability.
• Cover a full range of service processes, from solution customization to immediate use.
• Comprehensive suite of equipment instrumentation and analytical validation.

MHC cell lines play an important role in many stages of drug development, including drug validation and target validation. Please work with us to develop and construct the MHC cells you need.

Creative BioMart offers a complete range of innovative MHC-related products and services that can be tailored to your project. Whether you need technical support, consulting or development and testing services, working with us can accelerate the construction of your cell lines and move your project forward. With a wealth of experience, we are committed to being your most trusted partner. For more information, please contact us and our team will get back to you as soon as possible.

Reference

• Das K, et al. "Correction: Generation of murine tumor cell lines deficient in MHC molecule surface expression using the CRISPR/Cas9 system." PLOS ONE 13.12 (2018): e0209719.