Products

PE-Labeled Human HLA-G&B2M&Peptide Tetramer Protein

Overview Specification

Product Name	PE-Labeled Human HLA-G&B2M&Peptide Tetramer Protein
Cat. No.	MHCRP-0679
Category	Proteins & Peptides
Product Description	Recombinant PE-Labeled Human HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin. It contains Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide.
Size	100/500 μg
Format	Supplied as 0.22 μm filtered solution in PBS, 0.2% BSA (pH 7.4).
Shipping Temp	Shipped with dry ice.
Lead Time	Product delivery time depends on the supplier.
Species	Human
Expression Host	HEK293
Accession No	P17693-1(HLA-G)&P61769(B2M)&RIIPRHLQL
Tag	C-His-Avi
Tag Position	C-terminus
Molecular Type	Tetramer
Gene Synonyms	HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G
Amino Acid Range	Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide
Activity	Immobilized PE-Labeled human HLA-G&B2M&peptide (RIIPRHLQL) tetramer, His tag at 0.5 μg/mL (100 μL/well) on the plate. Dose response curve for anti-HLA-G antibody, hFc tag with the EC50 of 10.6 ng/mL determined by ELISA.
Product Background	HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.
Allele	HLA-G
Biotinylated	No

For research or industrial raw materials, not for personal medical use!