Products

PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D Tetramer

Overview Specification

Product Name	PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D Tetramer
Cat. No.	MHCRP-0656
Category	Proteins & Peptides
Product Description	Recombinant PE-Labeled Human HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. PE-labeled Human HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer is assembled by biotinylated monomer and PE-Labeled streptavidin. It contains Gly25-Thr305 (HLA-A*11:01), Ile21-Met119 (B2M) and VVVGADGVGK peptide.
Size	100/500 μg
Format	Liquid. Supplied as 0.22 μm filtered solution in PBS, 0.2% BSA (pH 7.4).
Storage	Store at -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping Temp	Shipped at ambient temperature.
Lead Time	Product delivery time depends on the supplier.
Species	Human
Expression Host	HEK293
Accession No	AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGADGVGK
Tag	C-His-Avi
Tag Position	C-terminus
Molecular Type	Tetramer
Gene Synonyms	MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD
Amino Acid Range	Gly25-Thr305 (HLA-A*11:01), Ile21-Met119 (B2M), and VVVGADGVGK peptide
Activity	Immobilized HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) TCR at 1 μg/mL (100 μL/well) on the plate. Dose response curve for PE-labeled human HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) tetramer, His tag with the EC50 of 96.7 ng/mL determined by ELISA.
Fluorophore	PE
Product Background	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target.
Allele	HLA-A*11:01
Biotinylated	No

For research or industrial raw materials, not for personal medical use!