Products

Human HLA-A*24:02&B2M&Survivin 2B Tetramer

Overview Specification

Product Name	Human HLA-A*24:02&B2M&Survivin 2B Tetramer
Cat. No.	MHCRP-0616
Category	Proteins & Peptides
Product Description	Recombinant Human Survivin 2B(HLA-A24:02) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus, tetramer is assembled by biotinylated monomer and streptavidin. It contains Gly25-Thr305 (HLA-A24:02), Ile21-Met119 (B2M) and AYACNTSTL peptide.
Size	100/500 μg
Format	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Storage	Store at -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping Temp	Shipped at ambient temperature.
Lead Time	Product delivery time depends on the supplier.
Species	Human
Expression Host	HEK293
Accession No	AAA59600.1(HLA-A*24:02)&P61769(B2M)&AYACNTSTL
Tag	C-His-Avi
Tag Position	C-terminus
Molecular Type	Tetramer
Molecular Weight (MV)	The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reduced (N) condition based on Bis-Tris PAGE result.
Gene Synonyms	svn-2B; Survivin-2B; svn 2B
Endotoxin Residue	Less than 1 EU per μg by the LAL method.
Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC.
Amino Acid Range	Gly25-Thr305 (HLA-A*24:02), Ile21-Met119 (B2M), and AYACNTSTL peptide
Product Background	Survivin-2B, a known splice variant of survivin, has been reported to promote cell death in some cancer cells, although it keeps prosurvival function in others. survivin-2B promoted autophagy and further regulated cell death by accumulating and stabilizing IKK alpha in the nucleus.
Allele	HLA-A*24:02
Biotinylated	No

For research or industrial raw materials, not for personal medical use!