Products

Human HLA-A*02:01&B2M&KKLC1 Tetramer

Overview Specification

Product Name	Human HLA-A*02:01&B2M&KKLC1 Tetramer
Cat. No.	MHCRP-0506
Category	Proteins & Peptides
Product Description	Recombinant Human HLA-A02:01&B2M&KKLC1 (ILNNFPHSI) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus, tetramer is assembled by biotinylated monomer and streptavidin. It contains Gly25-Thr305 (HLA-A02:01), Ile21-Met119 (B2M) and ILNNFPHSI peptide.
Size	100/500 μg
Format	Liquid. Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Storage	Store at -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping Temp	Shipped with dry ice.
Lead Time	Product delivery time depends on the supplier.
Species	Human
Expression Host	HEK293
Accession No	A0A140T913(HLA-A*02:01)&P61769(B2M)&ILNNFPHSI
Tag	C-His-Avi
Tag Position	C-terminus
Molecular Type	Tetramer
Molecular Weight (MV)	The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reduced (N) condition based on Bis-Tris PAGE result.
Gene Synonyms	KK-LC-1; CT83; CXorf61; KKLC1
Endotoxin Residue	Less than 1 EU per μg by the LAL method.
Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC.
Amino Acid Range	Gly25-Thr305 (HLA-A*02:01), Ile21-Met119 (B2M), and ILNNFPHSI peptide
Product Background	Kita-Kyushu lung cancer antigen-1 (KK-LC-1), encoded by CT83, includes epitope peptides recognized by cytotoxic T lymphocytes (CTLs). CTLs against KK-LC-1 predominantly accumulate among tumor-infiltrating lymphocytes, which leads to a good response to adaptive immunotherapy. Except for the testis, KK-LC-1 is not expressed in normal tissues. It is expressed in 33%, 82%, and 75% of non-small cell lung cancers, GC, and triple-negative breast cancers, respectively.
Allele	HLA-A*02:01
Biotinylated	No

For research or industrial raw materials, not for personal medical use!