Products

Human HLA-A*01:01&B2M&DSG3 Monomer

Overview Specification

Product Name	Human HLA-A*01:01&B2M&DSG3 Monomer
Cat. No.	MHCRP-0473
Category	Proteins & Peptides
Product Description	Recombinant Human HLA-A01:01&B2M&DSG3 (YTDNWLAVY) Monomer Protein is expressed from HEK293 with His tag and Avi Tag at the C-terminus. It contains Gly25-Thr305 (HLA-A01:01), Ile21-Met119 (B2M) and YTDNWLAVY peptide..
Size	100/500 μg
Format	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Storage	Store at -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping Temp	Shipped with dry ice.
Lead Time	Product delivery time depends on the supplier.
Species	Human
Expression Host	HEK293
Accession No	Q5SUL5(HLA-A*01:01)&P61769(B2M)&YTDNWLAVY
Tag	C-His-Avi
Tag Position	C-terminus
Molecular Type	Monomer
Molecular Weight (MV)	The protein has a predicted MW of 50.50 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Bis-Tris PAGE result.
Gene Synonyms	DSG3; DSG-3; Desmoglein-3; PVA; CDHF6; DG3
Endotoxin Residue	Less than 1 EU per μg by the LAL method.
Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC.
Amino Acid Range	Gly25-Thr305 (HLA-A*01:01), Ile21-Met119 (B2M), and YTDNWLAVY peptide.
Product Background	DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. DSG3 is identified overexpressed in HNC, with the degree of overexpression associated with clinicopathologic features of the tumor. Inhibition of DSG3 significantly suppresses carcinogenic potential in cellular and in vivo animal studies. These findings suggest that DSG3 is a potential molecular target in the development of adjuvant therapy for HNC.
Allele	HLA-A*01:01
Biotinylated	No

For research or industrial raw materials, not for personal medical use!