Products

Biotinylated Human HLA-A*11:01&B2M&RASL11B Monomer, HEK293

Overview Specification

Product Name	Biotinylated Human HLA-A*11:01&B2M&RASL11B Monomer, HEK293
Cat. No.	MHCRP-0423
Category	Proteins & Peptides
Product Description	Recombinant Biotinylated Human HLA-A11:01&B2M&RASL11B (AVVGASGVGK) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. It contains Gly25-Thr305 (HLA-A11:01), Ile21-Met119 (B2M) and AVVGASGVGK peptide.
Size	100/500 μg
Format	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Storage	Store at -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping Temp	Shipped with dry ice.
Lead Time	Product delivery time depends on the supplier.
Species	Human
Expression Host	HEK293
Accession No	AAV53343.1(HLA-A*11:01)&P61769(B2M)&AVVGASGVGK
Tag	C-His-Avi
Tag Position	C-terminus
Molecular Type	Monomer
Gene Synonyms	RAS11B; AVVGASGVGK; MHC
Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC.
Amino Acid Range	Gly25-Thr305 (HLA-A*11:01), Ile21-Met119 (B2M), and AVVGASGVGK peptide
Product Background	RAS (H-ras, K-ras, and N-ras), as the second largest mutated gene driver in various human cancers, has long been a vital research target for cancer. Its function is to transform the extracellular environment into a cascade of intracellular signal transduction. RAS mutant protein regulates tumor cell proliferation, apoptosis, metabolism and angiogenesis through downstream MAPK, PI3K and other signaling pathways.
Biotinylated	Yes

For research or industrial raw materials, not for personal medical use!