Products

Biotinylated Human HLA-A*11:01&B2M&RASL11B Monomer, E. coli

Overview Specification

Product Name	Biotinylated Human HLA-A*11:01&B2M&RASL11B Monomer, E. coli
Cat. No.	MHCRP-0422
Category	Proteins & Peptides
Product Description	Recombinant Biotinylated Human HLA-A11:01&B2M&RASL11B (AVVGASGVGK) Monomer Protein is expressed from E. coli* with His tag and Avi tag at the C-terminus. It contains Gly25-Thr305 (HLA-A*11:01), Ile21-Met119 (B2M) and AVVGASGVGK peptide.
Size	100/500 μg
Format	Liquid. Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Storage	Store at -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping Temp	Shipped with dry ice.
Lead Time	Product delivery time depends on the supplier.
Species	Human
Expression Host	E. coli
Accession No	AAV53343.1(HLA-A*11:01)&P61769(B2M)&AVVGASGVGK
Tag	C-His-Avi
Tag Position	C-terminus
Molecular Type	Monomer
Molecular Weight (MV)	The protein has a predicted MW of 35.36 kDa (HLA-A*11:01) and 11.9 kDa (B2M) same as Bis-Tris PAGE result.
Gene Synonyms	RAS11B; AVVGASGVGK; RASL11B
Endotoxin Residue	Less than 1 EU per μg by the LAL method.
Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC.
Amino Acid Range	Gly25-Thr305 (HLA-A*11:01), Ile21-Met119 (B2M), and AVVGASGVGK peptide
Product Background	RAS (H-ras, K-ras, and N-ras), as the second largest mutated gene driver in various human cancers, has long been a vital research target for cancer. Its function is to transform the extracellular environment into a cascade of intracellular signal transduction. RAS mutant protein regulates tumor cell proliferation, apoptosis, metabolism and angiogenesis through downstream MAPK, PI3K and other signaling pathways.
Allele	HLA-A*11:01
Biotinylated	Yes

For research or industrial raw materials, not for personal medical use!