Products

Biotinylated Human HLA-A*02:01&B2M&KKLC1 Monomer

Overview Specification

Product Name	Biotinylated Human HLA-A*02:01&B2M&KKLC1 Monomer
Cat. No.	MHCRP-0353
Category	Proteins & Peptides
Product Description	Recombinant Biotinylated Human HLA-A02:01&B2M&KKLC1 (ILNNFPHSI) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. It contains Gly25-Thr305 (HLA-A02:01), Ile21-Met119 (B2M) and ILNNFPHSI peptide.
Size	100/500 μg
Format	Liquid. Supplied as 0.22 μm filtered solution in PBS, 100 mM L-arginine (pH 7.4).
Storage	Store at -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping Temp	Shipped at ambient temperature.
Lead Time	Product delivery time depends on the supplier.
Species	Human
Expression Host	HEK293
Accession No	A0A140T913(HLA-A*02:01)&P61769(B2M)&ILNNFPHSI
Tag	C-His-Avi
Tag Position	C-terminus
Molecular Type	Monomer
Molecular Weight (MV)	The protein has a predicted MW of 50.50 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Bis-Tris PAGE result.
Gene Synonyms	KKLC1; KK-LC-1; CT83; CXorf61
Endotoxin Residue	Less than 1 EU per μg by the LAL method.
Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC.
Amino Acid Range	Gly25-Thr305 (HLA-A*02:01), Ile21-Met119 (B2M), and ILNNFPHSI peptide
Product Background	ILNNFPHSI is a peptide epitope derived from KKLC1 (also known as Kita-kyushu lung cancer antigen 1, CT83 or CXorf61) that is naturally processed and presented on the cell surface in complex with MHC class I molecules. This peptide, together with binding moieties that specifically recognize the peptide–MHC complex, provides a valuable basis for the development of therapeutic agents capable of selectively targeting KKLC1-expressing cancer cells, and holds particular promise for the treatment of malignancies such as non-small cell lung cancer (adenocarcinoma and squamous subtypes) and esophageal cancer.
Allele	HLA-A*02:01
Biotinylated	Yes

For research or industrial raw materials, not for personal medical use!